Istanbul to Athens (Piraeus)

A chaotic, colossal collision of east and west – start your day in Europe and end it in Asia, all without breaking a sweat. Sprawling across two continents, the city has been toed, froed and yanked between countless civilisations over its history, leaving a multi-layered, majestic tapestry of culture to untangle. An army of narrow minarets puncture the skyline, while the soaring towers of palaces and labyrinths of bazaars - where bargains are the reward for brave hagglers - fill up this dynamic city of 15 million people. View less With a rich portfolio of Byzantine and Ottoman architecture, Istanbul enjoys one of the world's most dynamic skylines and has an intense, infectious energy. The vast Aya Sofya is the starting point for exploring this huge city's deep wealth of cultural treasures. Built in the 6th century as a Greek Orthodox church, it was later transformed into an Ottoman imperial mosque – and latterly a museum. Cast your eyes up to take in the full scale of the colossal dome, one of the world's largest, which floats on a magnificent bed of light. See the Blue Mosque, with its glorious blue İznik tiles, or head to the Galata Tower which was once the tallest structure in Istanbul, and is ideal for a panoramic view of the city. Grab handfuls of dates and spices, shop for jewellery and patterned fabrics as you're swallowed whole by the Grand Bazaar - one of the world's biggest and busiest covered indoor markets. To understand Istanbul is to visit its kahvehans. Few rituals are taken as seriously as Turkish coffee - prepared to be incredibly strong. Sweeten the aftertaste with Turkish delight, or baklava – try the smooth pistachio version called kuru baklava.

Since the late 1970s, Kusadasi has grown from a fishing village into a sprawling tourist center, serving thousands of visitors who flock here to visit the nearby ruins of Ephesus. Despite an incredible building boom and an influx of shops, Kusadasi has managed to retain much of its original charm. The major attraction remains the archaeological site of ancient Ephesus, considered to be the most important one in all of Turkey. The history of this ancient city dates as far back as the 10th century BC. Many of the remarkable structures seen today are the result of an extraordinary excavation and restoration program. As you walk along the white marble road, grooved by ancient chariot wheels, the two-story Library of Celsus presents a striking sight. In addition, there are temples, houses of noblemen and community buildings lining the ancient streets. Nestled into the mountainside is the 25,000-seat amphitheater, still used today for performances during the Festival of Culture and Art.

Çeşme is a Turkish resort town west of Izmir, on the Aegean Sea. Overlooking the harbor is Çeşme Castle, a restored military fortress. It now houses the Çeşme Archaeology Museum, with displays of marble busts, metal coins and artifacts from nearby excavations. On the east side of the Çeşme peninsula is sandy Ilica Beach, with warm thermal sulfur springs. Around Çeşme are clear waters and accessible dive sites

Located only seven miles from the Turkish coast, Rhodes is one of Greece's favored vacation centers. In ancient times, the entrance to its harbor featured a celebrated landmark, the Colossus of Rhodes. The 105-foot statue rose from a 35-foot stone base and was considered one of the Seven Wonders of the Ancient World. Rhodes was an important cultural center with a well-known School of Rhetoric attended by such historical figures as Cicero and Caesar. From a school for sculptors came the famous Laocoon group, which is now in the Vatican Museum. Rhodes' most famous attractions originated with the Knights of St. John, who occupied parts of the island from 1308 to 1522. As their legacy they left a medieval town, dominated by the Palace of the Grand Masters and the Knights' Hospital. The Old Town is encircled by one of the best-preserved walls in Europe. In addition to buildings that showcase the legacy of the Knights of St. John, there are plenty of shops and dining opportunities throughout the Old Town.

Of all the Cyclades Islands, Santorini is often considered the most dramatic. Once an active volcano, in approximately 1620 BC, the volcano erupted with such force that the center of the island literally exploded, leaving a submerged crater. The island's small villages were preserved in the ashes giving a fascinating view of everyday life from 3,600 years ago. Santorini's landscape offsets its simple buildings, which shine in the brilliant sunlight. The rich volcanic soil is ideal for grapes and the local vines produce a crop known for its "special volcanic taste."

Egypt's main port and second largest city after Cairo was built between 332-331 BC at the order of Alexander the Great. Immortalizing his name, the city quickly flourished into a prominent cultural, political and economical metropolis, home to the famous Bibliotheca Alexandrina. It was the renowned capital of the Ptolemies and the site of the Pharos Lighthouse, one of the Seven Wonders of the Ancient World.

Egypt's main port and second largest city after Cairo was built between 332-331 BC at the order of Alexander the Great. Immortalizing his name, the city quickly flourished into a prominent cultural, political and economical metropolis, home to the famous Bibliotheca Alexandrina. It was the renowned capital of the Ptolemies and the site of the Pharos Lighthouse, one of the Seven Wonders of the Ancient World.