Piraeus (Athens) to Fusina (Venice)

The Holy Isle of Patmos, one of the smaller Dodecanese Islands, occupies a narrow strip of land with numerous rocky hills and scant vegetation. The interior is sparsely populated with mostly shepherds and fishermen. In contrast, the waterfront areas see plenty of tourists during the summer months. There are only two main villages, Chora and Scala; whitewashed houses face Scala harbor or are scattered over the hillsides. The island's mild, healthy climate, year-round sunshine, delightful coves and numerous chapels combine to form a picture of unique beauty. The history of Patmos can be traced to Dorian and Ionian settlers who established a sanctuary to worship the goddess Artemis.

Of all the Cyclades Islands, Santorini is often considered the most dramatic. Once an active volcano, in approximately 1620 BC, the volcano erupted with such force that the center of the island literally exploded, leaving a submerged crater. The island's small villages were preserved in the ashes giving a fascinating view of everyday life from 3,600 years ago. Santorini's landscape offsets its simple buildings, which shine in the brilliant sunlight. The rich volcanic soil is ideal for grapes and the local vines produce a crop known for its "special volcanic taste."

One of the most beautiful parts of this region of the Peloponnese is the plain of Laconia which extends from Sparta to the port of Gythion. The many neo-classical houses of this harbor town are built on the slopes of Mount Kourmaros. Aside from its remaining ancient theater and cultural museum, visitors can enjoy local beaches and a variety of dining opportunities. The inhabitants of Gythion claim Hercules and Apollo as its founders. According to mythology, Paris and Helen of Troy were reputed to have spent their first night together on nearby ancient Kranae, now called Marathonissi. Enlarging the natural harbor, it was used by the Spartans as their naval base and the main port of trade. Today Gythion is visited mostly for its scenic beauty and access to numerous historical sites. These include the cliffside city of Mistra, one of the finest surviving examples of Byzantine architecture in Greece, and ancient Sparta.

Split is a busy port with numerous ferries operating to and from nearby islands. It is also a popular resort with beaches, pleasant promenades and good hotels. Venetian Gothic and Renaissance houses and several medieval churches add architectural interest. As a major cultural center, Split does not lack in museums and art galleries. However, the city's principal attraction is Diocletian's Palace. It occupies an area of 34,680 square yards and was constructed to serve as a residence and a fortified military camp. By the Middle Ages, the palace had been enclosed within a strong wall with square corner towers, enclosing a town with narrow house-lined alleys. As the city grew, people gradually moved outside the walls and the city center shifted westward.

One of the most popular of the island escapes sprinkled across the turquoise Adriatic, Hvar is a glorious idyll of hidden coves, electric blue waters and quietly contented port towns. In recent years, it’s gathered something of a reputation as a party island - mainly earned from Hvar Town’s nocturnal exuberances, and the transient day-tripping yachts that drop by. View less Soak up the energy, exuberance and fine dining, or sidestep the hedonism to explore a richly refined, rural and historic island – utterly spoiled with sunshine, and hidden beaches, which dazzle with colourful intensity. Bike rides along long sweeping coastal paths, boat journeys from pretty harbours, walks through fields of purple lavender - it’s all waiting for you on heavenly Hvar. Relish the sunshine and explore deserted, idyllic inlets, before sharing strong espressos in quiet harbour towns, surrounded by welcoming, sun-wrinkled locals. There’s also rich Medieval history – the sleepy town of Stari Grad is said to be Croatia’s oldest, dating back to 384 BC. Elsewhere, Jelsa is a postcard perfect place – settle in for a bite to eat, with nothing but the sound of harbour waters lapping and sandpaper scraping boats hulls for company. You can walk to look out over glorious views across to Brac, sometimes watching on as thunderstorms rage and flash, an eternity away over the mainland’s crumpled mountains. You’re also just a short ferry ride from the incredible Golden Horn - an evocative spike of brilliant sand which juts out evocatively into the cobalt-blue sea.

Croatia’s Capital of Cool, Zadar is a dazzling mesh of influences and creativity. Romans founded the city before the Venetians, Austrians, French and Italians all had their say, leaving a wealth of architectural interest. Glorious turquoise-water beaches and heavenly waterfalls also lie within easy reach of this energetic city of festivals and outdoor fun. See the old town, with its robust city walls, boasting decorative stone gateways and marble streets. View less The church of St Donatus, was built from stones pillaged from the Roman forum, while Zadar Cathedral - Dalmatia's biggest - stands among the many architectural treats of this city, which was once an impenetrable stronghold of Venice’s republic. Head for the ‘pillar of shame’ with its chains to humiliate the criminals of a bygone time - or succumb to the tempting treats of shopping in the market. The sparkling Adriatic’s waters calls you, and Kolovare Beach is a mere ten-minute stroll from the old town. A day trip to Kornat National Park - which incorporates the Zadar Archipelago's immaculate scattering of beach-fringed islands - or to the divine waterfalls of Plitvice Lakes National Park, will introduce you to more of Croatia’s thrilling natural beauty. The sea truly does sing here in Zadar, thanks to a unique waterfront artwork, which encapsulates the city’s playful spirit. Designed to make music when the waves wash over it, the ebb and flow of the Adriatic, plays the Sea Organ instrument like a maestro. Not far away, the Monument to the Sun is a 22-metre-wide disc, which gathers the sun’s rays during the sunny days, and releases the solar energy in the form of a magical light show after dark. Sit and admire the artwork coming to life, as one of the city’s famous sunsets plays out before you.

Rijeka is a Croatian port city on Kvarner Bay in the northern Adriatic Sea. It’s known as a gateway to Croatia’s islands. Korzo, the main promenade, is lined with Habsburg-era buildings. Nearby, the 19th-century Ivan pl. Zajc Croatian National Theatre has ceiling paintings by Gustav Klimt. The hilltop Trsat Castle complex, which includes a religious shrine, has sweeping views of the islands of Kvarner Bay.

Koper is a port city in Slovenia, on the country's Adriatic coastline. Its medieval old town centers around Titov Trg, a square with Venetian-influenced landmarks such as the Praetorian Palace and a Gothic-style loggia, while nearby Da Ponte Fountain is a replica of Venice's famed Rialto Bridge

Losing none of its allure over the years, this floating city of canals, bridges and masks is a place of eternal beauty and enduring elegance. The lagoon of more than 100 islands is a heavenly sight, transporting visitors on a journey through time - from its Roman inception, through centuries of trade to the modern face we see today. Navigate Venice’s sparkling waterways by romantic gondola, or on cruises along wide canal boulevards. Span the Grand Canal over its iconic original crossing, the Rialto Bridge, which - with its parade of tiny shops - gives some of the city’s most endearing views. If the crowds unsettle you at any point, take two turns away from the main thoroughfares to find peace alone, amid the city's labyrinth of tiny streets. Hurry to Piazza San Marco to be immersed in Venice’s elegant glory. Basilica San Marco transports you back to the wealthy days of the Doges, who ruled for over 1,000 years. Initially their private chapel, it’s now decorated with beautiful Byzantine mosaics. Nearby the Campanile di San Marco bell tower offers views over the higgledy-piggledy rooftops of times gone by. Just a hop skip and a jump around the corner is the Doge’s Palace, where the levels of opulence ramp up even further. Justice was meted out in this stunning Palace, with the guilty walking to the cells across the covered Bridge of Sighs. Vaporetto trips to local islands offer even more adventures to float your boat, whether it’s Murano with its world-famous glass, Torcello with its amazing Cathedrals, or Burano with its handmade lace and delightfully colourful painted houses.