21-Day Iberia & Mediterranean: Spain, Italy & Greece

Often called the gateway to Europe, the port city of Rotterdam is full of old-world charm. The harbor offers amazing views and a maze of wharves and canals, along with towering spires make for a beautiful sight. Take a stroll and duck into one of the pubs or eateries along the way. Only three pre World War II buildings in the city centre have survived and are worth a look - city hall, St. Laurence church and the White House. Explore the Museum Boymans van Beuningen, which houses a unique collection dating from the 14th century, or the Museum Voor Volkenkunde - home to ethnological exhibits. Exquisite architecture can be seen in many areas of Rotterdam, most notably in the Delfshaven quarter of the city - where 18th century houses are on display. For a laugh, check out Kijk-Kubus, an upside-down house.

This Basque city combines a heady mix of ancient roots and ultramodern sensibilities. If you like modern design, Bilbao’s got striking architecture—like Frank Gehry’s shiplike Guggenheim Museum, the soaring Isozaki towers and Calatrava’s glass-bottomed Zubizuri Bridge. If you seek older cultural highlights, there are historic buildings, traditional Basque cuisine and inviting cobblestone streets to explore. Outside Bilbao’s bustling center, there’s lots to discover. Find sweeping views and surprising meals—both traditional and avant-garde—waiting to be savored in hilltop communities. Learn about the Basques’ tragic history and promising future in Guernica, the city bombed by Fascist forces and immortalized by Picasso. Or spend a day in San Sebastián, exploring the historic center, the boardwalk and the curving bay, setting some time aside to sample the city's famous Michelin-star worthy cuisine.

Find your way in the city that launched the Age of Discovery. Cross the River Tagus on its soaring suspension bridge, watched over by a colossal statue of Christ. Wander the maze of streets in the Alfama, the old Moorish quarter, dominated by the medieval Castle of St George where peacocks strut and shriek. Stroll the Baixa and refuse to leave without a pair of elegant shoes.

There are more than two millennia of history to embrace in this port city in Spain's southeastern Murcia region. While Cartagena is famously home to the second-largest Roman amphitheater on the Iberian Peninsula, the city is much more than just spectacular ancient ruins. In addition to Cartagena’s architecture—along with that amphitheater, there are striking Art Nouveau buildings, neoclassical churches and ultramodern edifices throughout the city—you’ll find many opportunities to shop for local and regional artisan wares. In the city, investigate the restored medieval fortress looking out on the bay from the city’s highest point. Or take a short trip by car or bus to the historic Agrupa Vicenta Mines, the remarkable palm forest at Elche and the holy city of Caravaca. And the food of sunny Murcia! Friendly tapas bars with breezy terraces invite lingering over drinks, coffee or snacks. The local restaurants offer more than typical Spanish tapas on the menu—michirones (a spicy Murcian bean stew) and local spins on paella are widely available and worth a try. Grilled octopus, fried calamari, mussels and the freshest fish are some of the tasty benefits of the city’s perch beside the sea.

Famous for paella at Pepica's, favorite of Ernest Hemingway when he came to Valencia for bullfight festivals. Overlooking the Gulf of Valencia and the Balearic Islands, this Spanish jewel blends ancient and new in its historic center, where the Barrio del Carmen neighborhood uses the old walls of the city in its more modern structures. Walk the cobblestone streets to the chic Colon Street, home to local boutiques-or take in the sublime views from Las Arenas beach or one of the many delightful plazas. Sample shore excursions: Valencia City Tour.

On the northeast coast of Spain, overlooking the Mediterranean, Barcelona is a vibrant port city, packed with centuries of iconic art and architecture—Gaudí and Picasso both called it home—and lined with sunny white-sand beaches. Explore the Catalan capital's tourist attractions and historic neighborhoods, Modernisme and world-renowned art museums, galleries and local crafts shops—some of which are centuries old and stock traditional Catalan wares. After you see the sights, there are lively tapas bars around every corner where you can stop for a drink, a café amb llet (Catalan for espresso with steamed milk) or a snack, no matter the hour. Green spaces for picnics, long walks and respite from the hustle and bustle are scattered throughout Barcelona's attractions: There's Gaudí's mosaic-decorated park, a neoclassical maze at the Laberint d'Horta, as well as plenty of high places (mountains, monuments and edifices) where sightseeing visitors can take in the view. A short trip from Barcelona by car or train, luxury outlets, cava wineries, a mountaintop abbey and the sandy beaches of the Mediterranean coast await.

Marseille, in the south of France, has more spice, grit and edge than the Provençal towns that surround it. A trade city since the time of ancient Greece, the port always seems to be on the brink of change, generating a certain energy that’s hard to find in the timeless and traditional countryside. In fact, sometimes it doesn't seem very French at all. Thanks to a multicultural population, the culinary scene (with seafood dishes and Michelin-starred restaurants galore) goes beyond the classic steak frites at bistros and brasseries. A 19th-century cathedral presides over the city and the working-class Le Panier district has winding streets flanked by fading facades, while Baroque edifices grace the commercial thoroughfare La Canebière, once compared to the Champs-Élysées. Marseille’s 2013 turn as the European Capital of Culture sprouted a crop of cultural venues, from striking museums to cutting-edge gallery spaces and thought-provoking concept shops that showcase local talent. The waterfront has been refurbished—and on sunny days, it’s the place for people- and boat-watching from restaurants famous for bouillabaisse or outdoor cafés serving glasses of rosé and pastis.

When you embark on a cruise to Rome with Holland America Line you experience its bustling modernism along with its rich history. You can walk in the footsteps of emperors, have coffee in Renaissance piazzas and see contemporary art all in one afternoon. Your sightseeing time in Rome begins at the nearby port of Civitavecchia, a seaside town with roots that stretch back to the Etruscan era. Take note of the Forte Michelangelo (both Bramante and Michelangelo had a hand in its design), and the lungomare, a lively stretch along the sea with beach clubs, bars and restaurants. Once in the Eternal City you can fill your day with museums, churches, archaeological sites, traditional trattorias, artisan shops and, of course, gelato. The Colosseum and the Vatican Museums are Rome's superstar attractions, but there are plenty of quieter gems to explore. For food lovers there are the markets in Campo de' Fiori or the slightly farther flung Testaccio. The hip neighborhood of Monti, next to the Colosseum, has a vibrant piazza scene and boutique shopping, while the Villa Borghese offers a green oasis with a view towards Saint Peter’s Basilica and the masterpiece-filled Galleria Borghese. Although Rome might not have been built in one day, you'll certainly be able to see its highlights on our Rome cruises along with the top things to do there in 24 hours.

Rising behind the wide curve of its bay with brooding Mount Vesuvius and the deep blue sea as a backdrop, Naples, Italy enjoys a magnificent natural setting. It is the third-largest city in Italy after Rome and Milan, and arguably the most colorful and seductive of them all: Splendor and squalor live side by side in 21st-century Naples, and the mix is intoxicating. Cruise to Naples, home to world-class museums and attractions. Naples has something for everyone - superb restaurants, eclectic shopping, a thriving contemporary art scene and an edgy and vibrant street life. But once you’ve had enough of the pounding traffic and jostling crowds while sightseeing in Naples, there are endless opportunities for exploration further afield. The celebrated Roman ruins of Pompeii and Herculaneum, both victims of Vesuvius’ devastating 79 C.E. eruption, lie just south of the city. Explore Naples' history or take a short ride over to the island of Capri on a Naples shore excursion. The delightful town of Sorrento and the magnificent scenery of the Amalfi Coast are also within easy reach, and the dolce vita glamour of Capri—not to mention the healing thermal waters of Ischia—are a short hydrofoil hop from the mainland. Naples cruises offer a perfect mix of cultural and natural attractions.

Kotor is located along one of Montenegro's most beautiful bays. First settled during the days of ancient Rome, the city today has a well preserved urban centre with a vibrant community. Medieval architecture and numerous monuments of cultural heritage have made Kotor a UNESCO listed “World Natural and Historical Heritage Site."

No modern metropolis is more steeped in myth than Athens, Greece. From the gritty port of Piraeus—gateway to Greece’s fabled isles—to the Parthenon—eternal symbol of Western civilization—Athens has attracted adventurers and classicists for centuries. This heritage is still very much alive for modern visitors sightseeing in Athens: ancient stadiums and temples dwell alongside apartment blocks, modern performances are staged in the marble amphitheaters where Greek drama was born and millennia-old monuments are scattered in the archaeological park that circles the Acropolis. One of the world’s oldest maritime powers, Athens is blessed with a balmy climate and stunning coastline. The seaside suburbs of Athens are scalloped with sandy beaches, fancy yacht clubs and glamorous beach bars. While the Athenian lifestyle is known for late-night dinners and dancing until dawn, the city shines brightly by day in the bustling markets, lively cafés and fascinating museums that illuminate Greece's past and present. Contemplate the magnitude of all that culture and ancient tourist attractions while marveling at the sun setting into the Aegean or rising over the Acropolis.